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KMID : 0380620090410060717
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Korean Journal of Food Science and Technology
2009 Volume.41 No. 6 p.717 ~ p.721
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Anti-allergic Effect of Zizania latifolia Turcz Extracts
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Lee Eun-Jung
Yang Seun-Ah
Lee In-Seon
Whang Key
Hwang Eun-Young
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Abstract
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The anti-allergic effect of the methanol extract of Zizania latifolia Turcz was investigated. Methanol extract of Z. latifolia Trucz did not display any cytotoxicity activities in the IgE-sensitized RBL-2H3 cells. The extract was found to inhibit compound 48/80-induced degranulation and antigen-induced β-hexosaminidase release as well as PMA plus A23187-induced TNF-α production in RBL-2H3 mast cells in a dose-dependent manner. Release of β-hexosaminidase, a marker for the release of histamine in mast cells, was inhibited with an IC50 value of 73.8 μg/mL. These results suggest that Z. latifolia extracts may be useful for the prevention of type I allergic reaction.
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KEYWORD
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Zizania latifolia Turcz, β-hexosaminidase, degranulation, TNF-α, RBL-2H3 cells
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